- Title
- Ultrathin-strut biodegradable polymer versus durable polymer drug-eluting stents: a meta-analysis
- Creator
- Monjur, Mohammad Riashad; Said, Christian F.; Bamford, Paul; Parkinson, Michael; Szirt, Richard; Ford, Thomas
- Relation
- Open Heart Vol. 7, Issue 2, no. e001394
- Publisher Link
- http://dx.doi.org/10.1136/openhrt-2020-001394
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- journal article
- Date
- 2020
- Description
- Objectives: Determine whether an ultrathin biodegradable polymer sirolimus-eluting stent ('Orsiro' -BP-SES) has clinical benefits over second-generation durable polymer drug-eluting stents (DP-DES). Methods: We conducted a prospective systematic review and meta-analysis of randomised clinical trials comparing Orsiro BP-SES against DP-DES (PROSPERO Registration: CRD42019147136). The primary outcome was target lesion failure (TLF): composite of cardiac death, target vessel myocardial infarction (TVMI) and clinically indicated target lesion revascularisation (TLR)) evaluated at the longest available follow-up. Results: Nine trials randomised 11 302 patients to either Orsiro BP-SES or DP-DES. At mean weighted follow-up of 2.8 years, the primary outcome (TLF) occurred in 501 of 6089 (8.2%) participants with BP-SES compared with 495 of 5213 (9.5%) participants with DP-DES. This equates to an absolute risk reduction of 1.3% in TLF in favour of Orsiro BP-SES (OR 0.82; 95% CI 0.69 to 0.98; p=0.03). This was driven by a reduction in TVMI (OR 0.80; 95% CI 0.65 to 0.98; p=0.03). There were no significant differences in other clinical endpoints: cardiac death, TLR and stent thrombosis. Conclusion: The Orsiro BP-SES shows promising clinical outcomes in patients undergoing percutaneous coronary intervention compared with contemporary second-generation DES at a short to medium term follow-up. More research is warranted to evaluate performance over a longer follow-up period and in different clinical and lesion subsets.
- Subject
- acute coronary syndrome; coronary artery disease; coronary intervention (PCI); coronary stenting; interventional cardiology; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1445964
- Identifier
- uon:42722
- Identifier
- ISSN:2398-595X
- Language
- eng
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